Blueprints of Signaling Interactions between Pattern Recognition Receptors: Implications for the Design of Vaccine Adjuvants

Innate immunity activation largely depends on recognition of microorganism structures by Pattern Recognition Receptors (PRRs). PRR downstream signaling results in production of pro- and anti-inflammatory cytokines and other mediators. Moreover, PRR engagement in antigen-presenting cells initiates th...

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Main Authors: Timmermans, Kim, Plantinga, Theo S., Kox, Matthijs, Vaneker, Michiel, Scheffer, Gert Jan, Adema, Gosse J., Joosten, Leo A. B., Netea, Mihai G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Vaccines
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592350/
https://ncbi.nlm.nih.gov/pubmed/23345580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00703-12
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