IL-1β processing in mechanical ventilation-induced inflammation is dependent on neutrophil factors rather than caspase-1

PURPOSE: Mechanical ventilation can cause ventilator-induced lung injury, characterized by a sterile inflammatory response in the lungs resulting in tissue damage and respiratory failure. The cytokine interleukin-1β (IL-1β) is thought to play an important role in the pathogenesis of ventilator-induc...

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Udgivet i:Intensive Care Med Exp
Main Authors: Timmermans, Kim, van der Wal, Selina EI, Vaneker, Michiel, van der Laak, Jeroen AWM, Netea, Mihai G, Pickkers, Peter, Scheffer, Gert Jan, Joosten, Leo AB, Kox, Matthijs
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797957/
https://ncbi.nlm.nih.gov/pubmed/26266796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2197-425X-1-8
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