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Genetically Altering the Thermodynamics and Kinetics of Hepatitis B Virus Capsid Assembly Has Profound Effects on Virus Replication in Cell Culture

Capsid (core) assembly is essential for hepatitis B virus (HBV) replication. We hypothesize that assembly kinetics and stability are tuned for optimal viral replication, not maximal assembly. Assembly effectors (AEfs) are small molecules proposed to disrupt this balance by inappropriately enhancing...

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Hlavní autoři: Tan, Zhenning, Maguire, Megan L., Loeb, Daniel D., Zlotnick, Adam
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592155/
https://ncbi.nlm.nih.gov/pubmed/23283960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03014-12
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