Pharmacokinetics and Pharmacodynamics of ASP2151, a Helicase-Primase Inhibitor, in a Murine Model of Herpes Simplex Virus Infection

ASP2151 (amenamevir) is a helicase-primase inhibitor against herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus. Here, to determine and analyze the correlation between the pharmacodynamic (PD) and pharmacokinetic (PK) parameters of ASP2151, we examined the PD profile of ASP2151 using...

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Detaylı Bibliyografya
Asıl Yazarlar: Katsumata, Kiyomitsu, Chono, Koji, Kato, Kota, Ohtsu, Yoshiaki, Takakura, Shoji, Kontani, Toru, Suzuki, Hiroshi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2013
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591930/
https://ncbi.nlm.nih.gov/pubmed/23274658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01803-12
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