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Coordinated Roles of Pregnane X Receptor and Constitutive Androstane Receptor in Autoinduction of Voriconazole Metabolism in Mice

The antifungal efficacy of voriconazole (VRC) differs among host species, with potent efficacy in humans but less in rodents. We investigated the possible involvement of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in the species-specific efficacy of VRC through pharmacokinet...

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מידע ביבליוגרפי
Main Authors: Ohbuchi, Masato, Yoshinari, Kouichi, Kaneko, Hayato, Matsumoto, Satoru, Inoue, Akiko, Kawamura, Akio, Usui, Takashi, Yamazoe, Yasushi
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591884/
https://ncbi.nlm.nih.gov/pubmed/23274663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01900-12
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