Coordinated Roles of Pregnane X Receptor and Constitutive Androstane Receptor in Autoinduction of Voriconazole Metabolism in Mice

The antifungal efficacy of voriconazole (VRC) differs among host species, with potent efficacy in humans but less in rodents. We investigated the possible involvement of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in the species-specific efficacy of VRC through pharmacokinet...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ohbuchi, Masato, Yoshinari, Kouichi, Kaneko, Hayato, Matsumoto, Satoru, Inoue, Akiko, Kawamura, Akio, Usui, Takashi, Yamazoe, Yasushi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591884/
https://ncbi.nlm.nih.gov/pubmed/23274663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01900-12
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados