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Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance.
The translation of human triosephosphate isomerase (TPI) mRNA normally terminates at codon 249 within exon 7, the final exon. Frameshift and nonsense mutations of the type that cause translation to terminate prematurely at or upstream of codon 189 within exon 6 reduce the level of nuclear TPI mRNA t...
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| Publicado no: | Mol Cell Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359158/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8065363/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.9.6317 |
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