Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal may differentially induce Sjögren's syndrome or systemic lupus erythematosus in BALB/c mice

Our previous work showed that immunization of rabbits with 4-hydroxy 2-nonenal-modified Ro60 (HNE-Ro60) accelerates autoimmunity. We extended this model into mice, hypothesizing that the severity of autoimmunity would be dependent on degree of HNE-modification of Ro60. Five groups of BALB/c mice (te...

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Autori principali: Kurien, Biji T., Porter, Andrew, Dorri, Yaser, Iqbal, Saqib, D'Souza, Anil, Singh, Anil, Asfa, Sima, Cartellieri, Marc, Matsumoto, Hiroyuki, Bachmann, Michael, Hensley, Kenneth, Scofield, R. Hal
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591494/
https://ncbi.nlm.nih.gov/pubmed/20946951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.10.687
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