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Combined Delivery of Paclitaxel and Tanespimycin via Micellar Nanocarriers: Pharmacokinetics, Efficacy and Metabolomic Analysis

BACKGROUND: Despite the promising anticancer efficacy observed in preclinical studies, paclitaxel and tanespimycin (17-AAG) combination therapy has yielded meager responses in a phase I clinical trial. One serious problem associated with paclitaxel/17-AAG combination therapy is the employment of lar...

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Hlavní autoři: Katragadda, Usha, Fan, Wei, Wang, Yingzhe, Teng, Quincy, Tan, Chalet
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591361/
https://ncbi.nlm.nih.gov/pubmed/23505544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058619
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