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Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.
We have analyzed the expression of human gamma-globin genes during development in F2 progeny of transgenic mice carrying two types of constructs. In the first type, gamma-globin genes were linked individually to large (approximately 4-kb) sequence fragments spanning locus control region (LCR) hypers...
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| Publicado no: | Mol Cell Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359135/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8065342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.9.6087 |
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