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Chemical Modifications of PhTX-I Myotoxin from Porthidium hyoprora Snake Venom: Effects on Structural, Enzymatic, and Pharmacological Properties

We recently described the isolation of a basic PLA(2) (PhTX-I) from Porthidium hyoprora snake venom. This toxin exhibits high catalytic activity, induces in vivo myotoxicity, moderates footpad edema, and causes in vitro neuromuscular blockade. Here, we describe the chemical modifications of specific...

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Bibliografiske detaljer
Main Authors: Huancahuire-Vega, Salomón, Corrêa, Daniel H. A., Hollanda, Luciana M., Lancellotti, Marcelo, Ramos, Carlos H. I., Ponce-Soto, Luis Alberto, Marangoni, Sergio
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591178/
https://ncbi.nlm.nih.gov/pubmed/23484072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/103494
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