Chemical Modifications of PhTX-I Myotoxin from Porthidium hyoprora Snake Venom: Effects on Structural, Enzymatic, and Pharmacological Properties

We recently described the isolation of a basic PLA(2) (PhTX-I) from Porthidium hyoprora snake venom. This toxin exhibits high catalytic activity, induces in vivo myotoxicity, moderates footpad edema, and causes in vitro neuromuscular blockade. Here, we describe the chemical modifications of specific...

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Bibliografske podrobnosti
Main Authors: Huancahuire-Vega, Salomón, Corrêa, Daniel H. A., Hollanda, Luciana M., Lancellotti, Marcelo, Ramos, Carlos H. I., Ponce-Soto, Luis Alberto, Marangoni, Sergio
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591178/
https://ncbi.nlm.nih.gov/pubmed/23484072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/103494
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