Protein-tyrosine phosphatase activity of CD45 is activated by sequential phosphorylation by two kinases.

We describe a potential regulatory mechanism for the transmembrane protein-tyrosine phosphatase CD45. Phosphorylation on both tyrosine and serine residues in vitro results in an activation of CD45 specifically toward one artificial substrate but not another. The activation of these kinases appears t...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Stover, D R, Walsh, K A
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1994
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359072/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7518565/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.8.5523-5532.1994
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