Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole Genome Sequencing

Meiotic recombination creates genetic diversity and ensures segregation of homologous chromosomes. Previous population analyses yielded results averaged among individuals and impacted by evolutionary pressures. Here we sequenced 99 sperm from an Asian male using the newly developed amplification met...

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Detalhes bibliográficos
Main Authors: Lu, Sijia, Zong, Chenghang, Fan, Wei, Yang, Mingyu, Li, Jinsen, Chapman, Alec R., Zhu, Ping, Hu, Xuesong, Xu, Liya, Yan, Liying, Bai, Fan, Qiao, Jie, Tang, Fuchou, Li, Ruiqiang, Xie, X. Sunney
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590491/
https://ncbi.nlm.nih.gov/pubmed/23258895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1229112
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