Nonlinear Optical Imaging for Sensitive Detection of Crystals in Bulk Amorphous Powders

The primary aim of this study was to evaluate the utility of second-order nonlinear imaging of chiral crystals (SONICC) to quantify crystallinity in drug–polymer blends, including solid dispersions. Second harmonic generation (SHG) can potentially exhibit scaling with crystallinity between linear an...

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Main Authors: KESTUR, UMESH S., WANAPUN, DUANGPORN, TOTH, SCOTT J., WEGIEL, LINDSAY A., SIMPSON, GARTH J., TAYLOR, LYNNE S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590305/
https://ncbi.nlm.nih.gov/pubmed/22847843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23280
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