Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here using a combined metabonomics approach compromising holistic (1)H-NMR profiling and targeted MS approache...

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Detalhes bibliográficos
Main Authors: Collino, Sebastiano, Montoliu, Ivan, Martin, François-Pierre J., Scherer, Max, Mari, Daniela, Salvioli, Stefano, Bucci, Laura, Ostan, Rita, Monti, Daniela, Biagi, Elena, Brigidi, Patrizia, Franceschi, Claudio, Rezzi, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590212/
https://ncbi.nlm.nih.gov/pubmed/23483888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056564
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