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Enhancement of tumor immunotherapy by deletion of the A(2A) adenosine receptor

The A(2A) adenosine receptor plays a critical and non-redundant role in suppressing inflammation at sites of hypoxia and tissue damage. The tumor microenvironment has high levels of adenosine as a result of hypoxia and ectopic expression of enzymes responsible for the generation of extracellular ade...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Waickman, Adam T., Alme, Angela, Senaldi, Liana, Zarek, Paul E., Horton, Maureen, Powell, Jonathan D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589752/
https://ncbi.nlm.nih.gov/pubmed/22116345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1155-7
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