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Tumor Evolution in Space: The Effects of Competition Colonization Tradeoffs on Tumor Invasion Dynamics

We apply competition colonization tradeoff models to tumor growth and invasion dynamics to explore the hypothesis that varying selection forces will result in predictable phenotypic differences in cells at the tumor invasive front compared to those in the core. Spatially, ecologically, and evolution...

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Main Authors: Orlando, Paul A., Gatenby, Robert A., Brown, Joel S.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589695/
https://ncbi.nlm.nih.gov/pubmed/23508890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00045
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