IGF-I Signaling Is Essential for FSH Stimulation of AKT and Steroidogenic Genes in Granulosa Cells

FSH and IGF-I synergistically stimulate gonadal steroid production; conversely, silencing the FSH or the IGF-I genes leads to infertility and hypogonadism. To determine the molecular link between these hormones, we examined the signaling cross talk downstream of their receptors. In human and rodent...

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Autors principals: Zhou, Ping, Baumgarten, Sarah C., Wu, Yanguang, Bennett, Jill, Winston, Nicola, Hirshfeld-Cytron, Jennifer, Stocco, Carlos
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589673/
https://ncbi.nlm.nih.gov/pubmed/23340251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1307
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