Population pharmacokinetic modeling of Sepantronium bromide (YM155), a small molecule survivin suppressant, in patients with non-small cell lung cancer, hormone refractory prostate cancer, or unresectable stage III or IV melanoma

Purpose Population pharmacokinetics (PK) of sepantronium bromide (YM155) was characterized in patients with non-small cell lung cancer, hormone refractory prostate cancer, or unresectable stage III or IV melanoma and enrolled in one of three phase 2 studies conducted in Europe or the U.S. Method Sep...

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Autores principales: Aoyama, Yumiko, Kaibara, Atsunori, Takada, Akitsugu, Nishimura, Tetsuya, Katashima, Masataka, Sawamoto, Taiji
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2012
Materias:
Phase II Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589632/
https://ncbi.nlm.nih.gov/pubmed/22892872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-012-9867-x
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