Rare allelic forms of PRDM9 associated with childhood leukemogenesis

One of the most rapidly evolving genes in humans, PRDM9, is a key determinant of the distribution of meiotic recombination events. Mutations in this meiotic-specific gene have previously been associated with male infertility in humans and recent studies suggest that PRDM9 may be involved in patholog...

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Autors principals: Hussin, Julie, Sinnett, Daniel, Casals, Ferran, Idaghdour, Youssef, Bruat, Vanessa, Saillour, Virginie, Healy, Jasmine, Grenier, Jean-Christophe, de Malliard, Thibault, Busche, Stephan, Spinella, Jean-François, Larivière, Mathieu, Gibson, Greg, Andersson, Anna, Holmfeldt, Linda, Ma, Jing, Wei, Lei, Zhang, Jinghui, Andelfinger, Gregor, Downing, James R., Mullighan, Charles G., Awadalla, Philip
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589531/
https://ncbi.nlm.nih.gov/pubmed/23222848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.144188.112
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