Strain Typing of Classical Scrapie by Transgenic Mouse Bioassay Using Protein Misfolding Cyclic Amplification to Replace Primary Passage

According to traditional murine bioassay methodology, prions must be serially passaged within a new host before a stable phenotype, and therefore a strain, can be assigned. Prions often transmit with difficulty from one species to another; a property termed the transmission barrier. Transgenic mouse...

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Main Authors: Beck, Katy E., Thorne, Leigh, Lockey, Richard, Vickery, Christopher M., Terry, Linda A., Bujdoso, Raymond, Spiropoulos, John
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589467/
https://ncbi.nlm.nih.gov/pubmed/23472112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057851
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