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Activation of Akt by Advanced Glycation End Products (AGEs): Involvement of IGF-1 Receptor and Caveolin-1

Diabetes is characterized by chronic hyperglycemia, which in turn facilitates the formation of advanced glycation end products (AGEs). AGEs activate signaling proteins such as Src, Akt and ERK1/2. However, the mechanisms by which AGEs activate these kinases remain unclear. We examined the effect of...

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Detalhes bibliográficos
Main Authors: Yang, Su-Jung, Chen, Chen-Yu, Chang, Geen-Dong, Wen, Hui-Chin, Chen, Ching-Yu, Chang, Shi-Chuan, Liao, Jyh-Fei, Chang, Chung-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589465/
https://ncbi.nlm.nih.gov/pubmed/23472139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058100
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