Expression of Recipient CD47 on Rat Insulinoma Cell Xenografts Prevents Macrophage-Mediated Rejection through SIRPα Inhibitory Signaling in Mice

We have previously proven that the interspecies incompatibility of CD47 is responsible for in vitro phagocytosis of xenogeneic cells by host macrophages. Utilizing an in vivo model in the present study, we investigated whether genetically engineered expression of mouse CD47 in rat insulinoma cells (...

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Autors principals: Teraoka, Yoshifumi, Ide, Kentaro, Morimoto, Hiroshi, Tahara, Hiroyuki, Ohdan, Hideki
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589424/
https://ncbi.nlm.nih.gov/pubmed/23472187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058359
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