Role for CD47-SIRPα signaling in xenograft rejection by macrophages

We have previously proven that human macrophages can phagocytose porcine cells even in the absence of Ab or complement opsonization, indicating that macrophages present a pivotal immunological obstacle to xenotransplantation. A recent report indicates that the signal regulatory protein (SIRP)α is a...

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Bibliografiske detaljer
Main Authors: Ide, Kentaro, Wang, Hui, Tahara, Hiroyuki, Liu, Jianxiang, Wang, Xiaoying, Asahara, Toshimasa, Sykes, Megan, Yang, Yong-Guang, Ohdan, Hideki
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829264/
https://ncbi.nlm.nih.gov/pubmed/17360380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609661104
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