Posaconazole Exhibits In Vitro and In Vivo Synergistic Antifungal Activity with Caspofungin or FK506 against Candida albicans

The object of this study was to test whether posaconazole, a broad-spectrum antifungal agent inhibiting ergosterol biosynthesis, exhibits synergy with the β-1,3 glucan synthase inhibitor caspofungin or the calcineurin inhibitor FK506 against the human fungal pathogen Candida albicans. Although curre...

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Bibliographic Details
Main Authors: Chen, Ying-Lien, Lehman, Virginia N., Averette, Anna F., Perfect, John R., Heitman, Joseph
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589401/
https://ncbi.nlm.nih.gov/pubmed/23472097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057672
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