AAV-mediated Overexpression of Human α7 Integrin Leads to Histological and Functional Improvement in Dystrophic Mice

Duchenne muscular dystrophy (DMD) is a severe muscle disease caused by mutations in the DMD gene, with loss of its gene product, dystrophin. Dystrophin helps link integral membrane proteins to the actin cytoskeleton and stabilizes the sarcolemma during muscle activity. We investigated an alternative...

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Hlavní autoři: Heller, Kristin N, Montgomery, Chrystal L, Janssen, Paul ML, Clark, K Reed, Mendell, Jerry R, Rodino-Klapac, Louise R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589167/
https://ncbi.nlm.nih.gov/pubmed/23319059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.281
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