AAV-mediated Overexpression of Human α7 Integrin Leads to Histological and Functional Improvement in Dystrophic Mice

Duchenne muscular dystrophy (DMD) is a severe muscle disease caused by mutations in the DMD gene, with loss of its gene product, dystrophin. Dystrophin helps link integral membrane proteins to the actin cytoskeleton and stabilizes the sarcolemma during muscle activity. We investigated an alternative...

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Autori principali: Heller, Kristin N, Montgomery, Chrystal L, Janssen, Paul ML, Clark, K Reed, Mendell, Jerry R, Rodino-Klapac, Louise R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589167/
https://ncbi.nlm.nih.gov/pubmed/23319059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.281
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