Optimizing Glioblastoma Temozolomide Chemotherapy Employing Lentiviral-based Anti-MGMT shRNA Technology

Despite treatments combining surgery, radiation-, and chemotherapy, patients affected by glioblastoma (GBM) have a limited prognosis. Addition of temozolomide (TMZ) to radiation therapy is the standard therapy in clinical application, but effectiveness of TMZ is limited by the tumor's overexpre...

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Autors principals: Viel, Thomas, Monfared, Parisa, Schelhaas, Sonja, Fricke, Inga B, Kuhlmann, Michael T, Fraefel, Cornel, Jacobs, Andreas H
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589165/
https://ncbi.nlm.nih.gov/pubmed/23319055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.278
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