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Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes(1,2). Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway(3); however, its role in β-cell function remain...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3589109/ https://ncbi.nlm.nih.gov/pubmed/22983116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2578 |
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