Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement

Delta-5 and delta-6 desaturases (D5D and D6D) are key enzymes in endogenous synthesis of long-chain PUFAs. In this sample of healthy subjects (n = 310), genotypes of single nucleotide polymorphisms (SNPs) rs174537, rs174561, and rs3834458 in the FADS1-FADS2 gene cluster were strongly associated with...

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Autori principali: Al-Hilal, Maryam, AlSaleh, Aseel, Maniou, Zoitsa, Lewis, Fiona J., Hall, Wendy L., Sanders, Thomas A. B., O'Dell, Sandra D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Patient-Oriented and Epidemiological Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588878/
https://ncbi.nlm.nih.gov/pubmed/23160180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P032276
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