Diabetic atherosclerosis in APOE(*)4 mice: synergy between lipoprotein metabolism and vascular inflammation

Diabetes is a major risk factor for cardiovascular disease. To examine how diabetes interacts with a mildly compromised lipid metabolism, we introduced the diabetogenic Ins2(C96Y/+) (Akita) mutation into mice expressing human apoE4 (E4) combined with either an overexpressing human LDL receptor gene...

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Bibliografiska uppgifter
Huvudupphovsmän: Johnson, Lance A., Kim, Hyung-Suk, Knudson, Melissa J., Nipp, C. Taylor, Yi, Xianwen, Maeda, Nobuyo
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588868/
https://ncbi.nlm.nih.gov/pubmed/23204275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M031435
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