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Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.

We recently identified Vav as a Ras-activating guanine nucleotide exchange factor (GEF) stimulated by a T-cell antigen receptor-coupled protein tyrosine kinase (PTK). Here, we describe a novel, protein kinase-independent alternative pathway of Vav activation. Phorbol ester, 1,2-diacylglycerol, or ce...

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Publicat a:Mol Cell Biol
Autors principals: Gulbins, E, Coggeshall, K M, Baier, G, Telford, D, Langlet, C, Baier-Bitterlich, G, Bonnefoy-Berard, N, Burn, P, Wittinghofer, A, Altman, A
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358848/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7516472/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4749-4758.1994
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