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N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

Plasma membrane targeting of Ras requires CAAX motif modifications together with a second signal from an adjacent polybasic domain or nearby cysteine palmitoylation sites. N-terminal myristoylation is known to restore membrane binding to H-ras C186S (C-186 is changed to S), a mutant protein in which...

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Udgivet i:Mol Cell Biol
Principais autores: Cadwallader, K A, Paterson, H, Macdonald, S G, Hancock, J F
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358845/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8007974/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4722-4730.1994
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