N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.
Plasma membrane targeting of Ras requires CAAX motif modifications together with a second signal from an adjacent polybasic domain or nearby cysteine palmitoylation sites. N-terminal myristoylation is known to restore membrane binding to H-ras C186S (C-186 is changed to S), a mutant protein in which...
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| 發表在: | Mol Cell Biol |
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| Principais autores: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
1994
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358845/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8007974/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4722-4730.1994 |
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