Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus.

A major question in carcinogenesis is, How can a normal cell accumulate multiple mutations in different genes on different chromosomes, when the mutation rate of each gene is in the range of 10(-8) to 10(-5) per cell division? We hypothesize that many mutations may not be isolated events but rather...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Li, C Y, Yandell, D W, Little, J B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358808/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8007946/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4373-4379.1994
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