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Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus.

A major question in carcinogenesis is, How can a normal cell accumulate multiple mutations in different genes on different chromosomes, when the mutation rate of each gene is in the range of 10(-8) to 10(-5) per cell division? We hypothesize that many mutations may not be isolated events but rather...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Principais autores: Li, C Y, Yandell, D W, Little, J B
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1994
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358808/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8007946/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4373-4379.1994
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