Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

The nuclear lamina consists of A- and B-type lamins. Mutations in LMNA cause many human diseases, including progeria, a premature aging syndrome, whereas LMNB1 duplication causes adult-onset autosomal dominant leukodystrophy (ADLD). LMNB1 is reduced in cells from progeria patients, but the significa...

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Detalhes bibliográficos
Main Authors: Dreesen, Oliver, Chojnowski, Alexandre, Ong, Peh Fern, Zhao, Tian Yun, Common, John E., Lunny, Declan, Lane, E. Birgitte, Lee, Shu Jin, Vardy, Leah A., Stewart, Colin L., Colman, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587829/
https://ncbi.nlm.nih.gov/pubmed/23439683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201206121
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