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ATF4-DEPENDENT TRANSCRIPTION MEDIATES SIGNALING OF AMINO ACID LIMITATION
Mammals respond to dietary nutrient fluctuations; for example, deficiency of dietary protein or an imbalance of essential amino acids activates an amino acid response (AAR) signal transduction pathway, consisting of detection of uncharged tRNA by GCN2 kinase, eIF2α phosphorylation, and ATF4 expressi...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3587693/ https://ncbi.nlm.nih.gov/pubmed/19800252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2009.05.008 |
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