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Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes

Acetate supplementation attenuates neuroglia activation in a rat model of neuroinflammation by a mechanism associated with an increase in brain acetyl-CoA, an alteration in histone acetylation, and reduction of interleukin (IL)-1β expression. We propose that reduced astroglial activation occurs by d...

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Main Authors: Soliman, Mahmoud L., Combs, Colin K., Rosenberger, Thad A.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587660/
https://ncbi.nlm.nih.gov/pubmed/23233245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-012-9426-4
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