The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes

BACKGROUND: Newborns display distinct immune responses that contribute to susceptibility to infection and reduced vaccine responses. Toll-like receptor (TLR) agonists may serve as vaccine adjuvants, when given individually or in combination, but responses of neonatal leukocytes to many TLR agonists...

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Autori principali: Dowling, David J., Tan, Zhen, Prokopowicz, Zofia M., Palmer, Christine D., Matthews, Maura-Ann H., Dietsch, Gregory N., Hershberg, Robert M., Levy, Ofer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587566/
https://ncbi.nlm.nih.gov/pubmed/23483986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058164
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