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γ-Secretase Inhibitor, DAPT Inhibits Self-renewal and Stemness Maintenance of Ovarian Cancer Stem-like Cells In Vitro

OBJECTIVE: The Notch signaling pathway plays an important role in the stem cell signaling network and contributes to tumorigenesis. However, the functions of Notch signaling in ovarian cancer stem cells (OCSCs) are not well understood. We aimed to investigate the effects of Notch blockade on self-re...

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Detalhes bibliográficos
Main Authors: Jiang, Li-yu, Zhang, Xiao-lei, Du, Ping, Zheng, Jian-hua
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag Berlin Heidelberg 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587542/
https://ncbi.nlm.nih.gov/pubmed/23482909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11670-011-0140-1
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