Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy

Malignant transformation by oncogenes requires additional genetic/epigenetic changes to overcome enhanced susceptibility to apoptosis. In the present study, we report that Bif-1 (Sh3glb1), a gene encoding a membrane curvature–driving endophilin protein, is a haploinsufficient tumor suppressor that p...

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Detalhes bibliográficos
Main Authors: Takahashi, Yoshinori, Hori, Tsukasa, Cooper, Timothy K., Liao, Jason, Desai, Neelam, Serfass, Jacob M., Young, Megan M., Park, Sungman, Izu, Yayoi, Wang, Hong-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587325/
https://ncbi.nlm.nih.gov/pubmed/23287860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-459826
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