Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells

Regulatory T cells (Tregs) play an essential role in preventing autoimmunity. Mutations in the forkhead box protein 3 (FOXP3) gene, which encodes a transcription factor critical for Treg function, result in a severe autoimmune disorder and the production of various autoantibodies in mice and in IPEX...

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Detalhes bibliográficos
Main Authors: Kinnunen, Tuure, Chamberlain, Nicolas, Morbach, Henner, Choi, Jinyoung, Kim, Sangtaek, Craft, Joseph, Mayer, Lloyd, Cancrini, Caterina, Passerini, Laura, Bacchetta, Rosa, Ochs, Hans D., Torgerson, Troy R., Meffre, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587322/
https://ncbi.nlm.nih.gov/pubmed/23223361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-457465
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