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Particle shape enhances specificity of antibody-displaying nanoparticles

Monoclonal antibodies are used in numerous therapeutic and diagnostic applications; however, their efficacy is contingent on specificity and avidity. Here, we show that presentation of antibodies on the surface of nonspherical particles enhances antibody specificity as well as avidity toward their t...

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Bibliographic Details
Main Authors: Barua, Sutapa, Yoo, Jin-Wook, Kolhar, Poornima, Wakankar, Aditya, Gokarn, Yatin R., Mitragotri, Samir
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587278/
https://ncbi.nlm.nih.gov/pubmed/23401509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216893110
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