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Particle shape enhances specificity of antibody-displaying nanoparticles

Monoclonal antibodies are used in numerous therapeutic and diagnostic applications; however, their efficacy is contingent on specificity and avidity. Here, we show that presentation of antibodies on the surface of nonspherical particles enhances antibody specificity as well as avidity toward their t...

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Detalhes bibliográficos
Main Authors: Barua, Sutapa, Yoo, Jin-Wook, Kolhar, Poornima, Wakankar, Aditya, Gokarn, Yatin R., Mitragotri, Samir
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587278/
https://ncbi.nlm.nih.gov/pubmed/23401509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216893110
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