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Analytical methods for physicochemical characterization of antibody drug conjugates

Antibody-drug conjugates (ADCs), produced through the chemical linkage of a potent small molecule cytotoxin (drug) to a monoclonal antibody, have more complex and heterogeneous structures than the corresponding antibodies. This review describes the analytical methods that have been used in their phy...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Wakankar, Aditya, Chen, Yan, Gokarn, Yatin, Jacobson, Fredric S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092617/
https://ncbi.nlm.nih.gov/pubmed/21441786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.2.14960
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