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Analytical methods for physicochemical characterization of antibody drug conjugates
Antibody-drug conjugates (ADCs), produced through the chemical linkage of a potent small molecule cytotoxin (drug) to a monoclonal antibody, have more complex and heterogeneous structures than the corresponding antibodies. This review describes the analytical methods that have been used in their phy...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092617/ https://ncbi.nlm.nih.gov/pubmed/21441786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.2.14960 |
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