Genomic responses in mouse models poorly mimic human inflammatory diseases

A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models m...

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Hauptverfasser: Seok, Junhee, Warren, H. Shaw, Cuenca, Alex G., Mindrinos, Michael N., Baker, Henry V., Xu, Weihong, Richards, Daniel R., McDonald-Smith, Grace P., Gao, Hong, Hennessy, Laura, Finnerty, Celeste C., López, Cecilia M., Honari, Shari, Moore, Ernest E., Minei, Joseph P., Cuschieri, Joseph, Bankey, Paul E., Johnson, Jeffrey L., Sperry, Jason, Nathens, Avery B., Billiar, Timothy R., West, Michael A., Jeschke, Marc G., Klein, Matthew B., Gamelli, Richard L., Gibran, Nicole S., Brownstein, Bernard H., Miller-Graziano, Carol, Calvano, Steve E., Mason, Philip H., Cobb, J. Perren, Rahme, Laurence G., Lowry, Stephen F., Maier, Ronald V., Moldawer, Lyle L., Herndon, David N., Davis, Ronald W., Xiao, Wenzhong, Tompkins, Ronald G., Abouhamze, Amer, Balis, Ulysses G. J., Camp, David G., De, Asit K., Harbrecht, Brian G., Hayden, Douglas L., Kaushal, Amit, O’Keefe, Grant E., Kotz, Kenneth T., Qian, Weijun, Schoenfeld, David A., Shapiro, Michael B., Silver, Geoffrey M., Smith, Richard D., Storey, John D., Tibshirani, Robert, Toner, Mehmet, Wilhelmy, Julie, Wispelwey, Bram, Wong, Wing H
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587220/
https://ncbi.nlm.nih.gov/pubmed/23401516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222878110
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