Genomic responses in mouse models poorly mimic human inflammatory diseases

A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models m...

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Główni autorzy: Seok, Junhee, Warren, H. Shaw, Cuenca, Alex G., Mindrinos, Michael N., Baker, Henry V., Xu, Weihong, Richards, Daniel R., McDonald-Smith, Grace P., Gao, Hong, Hennessy, Laura, Finnerty, Celeste C., López, Cecilia M., Honari, Shari, Moore, Ernest E., Minei, Joseph P., Cuschieri, Joseph, Bankey, Paul E., Johnson, Jeffrey L., Sperry, Jason, Nathens, Avery B., Billiar, Timothy R., West, Michael A., Jeschke, Marc G., Klein, Matthew B., Gamelli, Richard L., Gibran, Nicole S., Brownstein, Bernard H., Miller-Graziano, Carol, Calvano, Steve E., Mason, Philip H., Cobb, J. Perren, Rahme, Laurence G., Lowry, Stephen F., Maier, Ronald V., Moldawer, Lyle L., Herndon, David N., Davis, Ronald W., Xiao, Wenzhong, Tompkins, Ronald G., Abouhamze, Amer, Balis, Ulysses G. J., Camp, David G., De, Asit K., Harbrecht, Brian G., Hayden, Douglas L., Kaushal, Amit, O’Keefe, Grant E., Kotz, Kenneth T., Qian, Weijun, Schoenfeld, David A., Shapiro, Michael B., Silver, Geoffrey M., Smith, Richard D., Storey, John D., Tibshirani, Robert, Toner, Mehmet, Wilhelmy, Julie, Wispelwey, Bram, Wong, Wing H
Format: Artigo
Język:Inglês
Wydane: National Academy of Sciences 2013
Hasła przedmiotowe:
Biological Sciences
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587220/
https://ncbi.nlm.nih.gov/pubmed/23401516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222878110
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