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Mechanism of action and initial evaluation of a membrane active all-D-enantiomer antimicrobial peptidomimetic

Development of therapy against infections caused by antibiotic-resistant pathogens is a major unmet need in contemporary medicine. In previous work, our group chemically modified an antimicrobial peptidomimetic motif for targeted applications against cancer and obesity. Here, we show that the modifi...

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Detalhes bibliográficos
Main Authors: McGrath, Danielle M., Barbu, E. Magda, Driessen, Wouter H. P., Lasco, Todd M., Tarrand, Jeffrey J., Okhuysen, Pablo C., Kontoyiannis, Dimitrios P., Sidman, Richard L., Pasqualini, Renata, Arap, Wadih
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587187/
https://ncbi.nlm.nih.gov/pubmed/23345420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221924110
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