Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging

The activity of protein phosphatase-1 (PP1) inhibitor-1 (I-1) is antithetically modulated by the cAMP-protein kinase A (PKA) and Ca(2+)-protein kinase C (PKC) signaling axes. β-adrenergic (β-AR) stimulation results in PKA-phosphorylation of I-1 at threonine 35 (Thr35) and depressed PP1 activity, whi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Florea, Stela, Anjak, Ahmad, Cai, Wen-Feng, Qian, Jiang, Vafiadaki, Elizabeth, Figueria, Sarah, Haghighi, Kobra, Rubinstein, Jack, Lorenz, John, Kranias, Evangelia G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587163/
https://ncbi.nlm.nih.gov/pubmed/22777184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-012-0279-z
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados