Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers.

Protein dimerization facilitates cooperative, high-affinity interactions with DNA. Nuclear hormone receptors, for example, bind either as homodimers or as heterodimers with retinoid X receptors (RXR) to half-site repeats that are stabilized by protein-protein interactions mediated by residues within...

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Bibliographic Details

Published in:	Mol Cell Biol
Main Authors:	Cheskis, B, Freedman, L P
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis 1994
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358699/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8164684/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.5.3329-3338.1994
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