Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis

Osteoarthritis (OA) affects over 40 million people annually. We evaluated interleukin-1 receptor antagonist (IL-1ra) gene transfer in an equine model based on IL-1ra protein therapy which inhibits inflammation through blocking IL-1. Using the self-complementary adeno-associated virus (scAAV)IL-1ra e...

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Autors principals: Goodrich, Laurie R, Phillips, Jennifer N, McIlwraith, C Wayne, Foti, Stacey B, Grieger, Joshua C, Gray, Steven J, Samulski, R Jude
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
Matèries:
Methods - Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586798/
https://ncbi.nlm.nih.gov/pubmed/23385523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.61
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